We are working to develop new breakthrough drugs against diseases for which there are no appropriate therapeutic drugs. We are focusing our drug research on discovery and typically, at an early stage, out-licensing development to highly specialized companies at home and abroad. This drug research venture system should allow new compounds to be brought to market as quickly as possible.

NC-2600 / P2X4 receptor antagonist (for neuropathic pain)

Neuropathic pain is a debilitating condition that interferes with sufferers’ everyday lives. However, since there are few viable treatment options in terms if remedies, a new treatment needs to be developed.
In joint research with Kyushu University, we have developed a new formulation to treat neuropathic pain. Since FY2012, the Company has been carrying out research with the support of AMED and, during FY2014, discovered NC-2600. This is a development candidate, which appears to be potentially effective through oral administration. In fiscal 2017, we completed phase 1 testing. We are currently conducting licensing out activities of aimed at domestic and international companies.

NC-2800 / Delta opioid receptor agonist (for depression/anxiety)

NC-2800 is a chemical compound with strong potential as an anti-depression and anti-anxiety treatment that the Company discovered through collaborative study with the University of Tsukuba, Kitasato University, and the National Center of Neurology and Psychiatry.
NC-2800 was selected by AMED’s industry–academia collaboration program (ACT-M) in 2015 and, while receiving AMED’s support, we conducted preclinical trials.
As a result, this compound received high acclaim for its potential as a therapeutic drug candidate and, in January 2018, AMED’s CiCLE project selected it for public funding. AMED has given its support for this for the period March 30, 2018 until March 31, 2027. While receiving AMED’s continued support, we have been conducting development of a groundbreaking emotion-regulating agent with a mechanism for activating δ opioid receptors.

NC-2500 / XOR inhibitor (therapeutic medications for gout, hyperuricemia)

NC-2500 is a novel advanced xanthine oxidoreductase (XOR) inhibitor, having potential to reduce the risk of gout flare, one of major issues of current treatments for gout, and make a difference in gout treatment.
In the Phase-1 study, NC-2500 showed favorable urate-lowering properties, that is NC-2500 lowered serum urate levels gradually to the same extent as current XOR inhibitors through 7 days, which could decrease the risk of acute flare in gout patients. Acute flare due to rapid urate reduction is one of the major issues in the initial phase of current therapy, which impairs patients’ quality of life and adherence, frequently resulting in failing sufficient control of serum urate and then worsening the disease. NC-2500 is expected to have potential to resolve these issues by its unique profile of reducing urate to avoid acute flare, with no need of or minimal titration. As for safety, NC-2500 was well-tolerated and adverse events were infrequent, transient, mild, and comparable to placebo. Furthermore, NC-2500 was hardly excreted through the renal pathway, which can be a favorite profile for patients with renal impairment, frequently observed in gout.

NC-2700 / URAT-1 inhibitor (therapeutic medications for gout, hyperuricemia)

NC-2700 is a novel urate transporter 1 (URAT1) inhibitor, enhancing excretion urate to urine. NC-2700 showed not just a potent uricosuric effect, but also pH-raising of the urine with lowered pH in an animal model, which could decrease the risk of renal calculus and nephrotoxicity with urate crystal in the urine, the most common issue with current uricosuric therapy. NC-2700 is now ready to start a phase-1 clinical study.


Business Development We are interested in any opportunities of collaboration, partnering or licensing of our pipeline products and welcome any proposal on them. If you have any interest in any of our pipeline products, please contact our business development team bd@chemiphar.co.jp.
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Business Development Contact

If you have any interest in our pipeline, please contact our business development team bd@chemiphar.co.jp.

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